Author Tyler Hartman, MDMayo Clinic Emergency Medicine Residency Program death Myxedema coma is a rare but severe complication of myxedema It is a lifethreatening complication with a mortality rate of 25–60 percent and tends toMyxedema coma has been most commonly reported in Doberman pinschers Coma myxoedémateux a été le plus fréquemment rapportés chez Doberman pinscher Myxedema coma occurs in some people with severe hypothyroidism who are exposed to some kind of stress, such as an infection, severe cold, trauma, or the use of sedatives Le coma myxœdémateux se produit
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Myxedema coma scale-Patients with myxedema coma, such as hypotension, hypoglycemia, hyponatremia, hyperkalemia, hypercalcemia, lymphocytosis, and azotemia In most patients with myxedema coma, the serum cortisol concentrations are within the reference range It is generally deemed prudent to treat with hydrocortisone because of the possibility of coexistent primary or secondary adrenal Myxedema Coma Overview The thyroid gland, located at the front part of the neck, is responsible for making substances called thyroid hormones that are
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Myxedema coma (MC) is a rare form of extreme hypothyroidism, with a mortality rate that may approach 60% 1 KluboGwiezdzinska J Wartofsky L Thyroid emergencies Med Clin North Am 12; Myxedema coma is severe hypothyroidism leading to decreased mental status and slowed metabolism of multiple organs It is a medical emergency with a high mortality rate It is thankfully very rare nowadays, but still very popular in medical school and on boards We should have named this document "severe hypothyroidism", but that would not grab as much attention Myxedema coma occurs as a result of longstanding, undiagnosed, or undertreated hypothyroidism and is usually precipitated by a systemic illness Myxedema coma can result from any of the causes of hypothyroidism, most commonly chronic autoimmune thyroiditis It can also occur in patients who had thyroidectomy or underwent radioactive iodine therapy for
Scopus (90) Google Scholar The condition represents a state of decompensated hypothyroidism that usually occurs after a period Myxedema coma is rare with an incidence of 022 cases per million per year, however may cause high mortality rate (2560%) without early diagnosed and proper treatment The aim of this report is to share a case of hypothermia with myxedema coma and dyspnea at emergency department (ED) With the supplement of thyroxine, glucocorticoid and intensive supportiveMyxedema coma is an endocrinologic emergency and is the most clinically severe form of hypothyroidism 6466 Although it is rarely seen today, myxedema coma still carries a high risk of death unless treated promptly Signs and symptoms include hypothermia, bradycardia, altered mental status, hypotension, and eventual respiratory failure from hypoventilation and carbon
Une complication du myxœdème sous forme de coma myxoedémateux dans les deux tiers des cas se développe chez les femmes dont l'âge moyen est de 7075 ans En Europe, l'incidence du coma due à des pathologies thyroïdiennes sévères ne dépasse pas 0,22 par million d'habitants par an, au Japon ce chiffre est cinq fois plus élevé , , , , , , , Causes myxoedèmeL'hypothyroïdie survient lorsque la thyroïde cesse deComa myxœdémateux Myxoedema coma Y Reznik*, D Du Cheyron* Définition Le coma myxœdémateux se définit comme une insuffisance thyroïdienne profonde et prolongée aboutissant à un trouble cognitif allant du ralentissement psychomoteur majeur au coma dans un contexte d'hypothermie Un facteur déclenchant est souvent identifiable, comme une infection,
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Untreated or unrecognized hypothyroidism may progress to severe decompensated hypothyroidism or myxedema coma Relatively few cases are reported in the literature since the first case was apparently reported from the St Thomas Hospital in London in 1879 The paucity of cases may be due to either underreporting or improvement in the diagnosis and treatment of Myxedema coma is a rare lifethreatening clinical condition in patients with longstanding severe untreated hypothyroidism, in whom adaptive mechanisms fail to maintain homeostasis Most patients, however, are not comatose, and the entity rather represents a form of very severe, decompensated hypothyroidism Myxedema Coma patients will have little oxygen reserve and may desaturate quickly on intubation attempt;
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MYXEDEMA coma is the extreme clinical expression of hypothyroidism It is characterized by coma, hypothermia, cardiovascular collapse, hypoventilation, and severe metabolic derangements, including low serum sodium, hypoglycemia, and lactic acidosis Mild to moderate hypometabolism, lethargy, and sleepiness secondary to untreated hypothyroidismMyxedema coma is defined as severe hypothyroidism leading to decreased mental status, hypothermia, and other symptoms related to slowing of function in multiple organs It is a medical emergency with a high mortality rate Fortunately, it is now a rare presentation of hypothyroidism, likely due to earlier diagnosis as a result of the widespread availability of thyroidstimulatingUntreated or unrecognized hypothyroidism may progress to severe decompensated hypothyroidism or myxedema coma Relatively few cases are reported in the literature since the first case was apparently reported from the St Thomas Hospital in London in 1879 The paucity of cases may be due to either un
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La crise de myxœdème peut causer la mort, souvent en raison de complications dues à une infection, à des saignements ou à une insuffisance respiratoire C'est plus fréquent chez les femmes et les personnes de plus de 60 ans Elle peut également survenir pendant la grossesse Quelles sont les causes du myxœdème ? Myxedema coma during longterm amiodarone therapy Am J Med 1984 Oct 77 (4)7514 Nicoloff JT, LoPresti JS Myxedema coma A form of Myxedema coma is a rare fatal condition resulting from longstanding hypothyroidism with loss of the adaptive mechanism to maintain homeostasis Hypothyroidism due to any cause, including autoimmune disease, iodine deficiency, congenital abnormalities, or medications like lithium and amiodarone, can precipitate myxedema coma if left untreated Even with early
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The mortality rate in myxedema coma has historically been as high as 80% Some data suggest that aggressive management and early recognition have improved the mortality rate to 15% However, a more recent observational study was unable to show significant differences in outcome based on replacement therapeutic methods, with a mortality rate remaining high at Myxedema Coma Hypothyroidism is a disorder you need to know for your MedSurg classes and exams, and a myxedema coma is a critical care topic that builds on your knowledge of this disorder Myxedema coma is a lifethreatening complication of hypothyroidism known as decompensated hypothyroidism Though this complication contains the word coma Myxedema coma is the most severe form of hypothyroidism and carries a high mortality risk Patients are typically elderly women who present in winter with deteriorating mental status, hypothermia, bradycardia, and multisystem organ failure Aggressive therapy is required to avoid a fatal outcome Keywords Coma Hypothyroidism Thyroxine Triiodothyronine
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Myxedema coma or myxedema crisis is a lifethreatening complication of hypothyroidism Some symptoms of myxedema coma include fatigue, lethargy, depression, dry skin, and weight gain Mild myxedema coma usually is treated by a general practitioner or internist while moderate to severe myxedema coma is treated and managed by an endocrinologist Myxedema coma is a rare complication of severe hypothyroidism and a lifethreatening medical emergency Hypothyroidism is a relatively common condition involving the underproduction of hormones by the thyroid Symptoms of hypothyroidism can be vague but involve fatigue, weight gain, constipation, and cold intolerance, among othersMyxedema coma ko´mah a state of unconsciousness from which the patient cannot be aroused, even by powerful stimuli Traumatic brain injuries are the most frequent cause;
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Myxedema coma, the extreme manifestation of hypothyroidism, is an uncommon but potentially lethal condition Patients with hypothyroidism may exhibit a number of physiologic alterations to compensate for the lack of thyroid hormone If these homeostatic mechanisms are overwhelmed by factors such as infection, the patient may decompensate into myxedema coma Patients withDr Carlo Oller, emergency physician, talks about severe hypothyroidism, or myxedema comaTable I Diagnostic Scoring System for Myxedembdominal pain/constipation 5 Decreased intestinal motility 15 Paralytic ileus
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Myxedema coma Today we discussed the case of a young woman with history of hypothyroidism who was unhoused and not taking medications for 2 months, presenting with subacute onset fatigue, with periorbital and bilateral lower extremity edema and lower extremity hyperpigmentation, found to have profound hypothyroidism vs mild myxedema comaMyxedema can occur in the lower leg (pretibial myxedema) and behind the eyes (exophthalmos) Severe cases, requiring hospitalization can exhibit signs of hypothermia, hypoglycemia, hypotension, respiratory depression, and coma Cause Myxedema is known to occur in various forms of hyperthyroidism, including Graves disease One of the hallmarksIntravenous Thyroxine (T4) Administer empirically if suspected (eg Hypothyroidism history) Normal TSH does not exclude Myxedema Coma (eg Amiodaroneinduced Hypothyroidism) Standard Protocol (Thyroxine alone)
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Myxedema coma caused by pituitary or hypothalamic disease (secondary or tertiary hypothyroidism) is virtually indistinguishable at the bedside from that caused by primary hypothyroidism The laboratory diagnosis of central hypothyroidism is difficult because the TSH, total T4, and total T3 levels are all low, similar to the pattern seen in the low T3/low T4 "Myxedema Coma" is a misleading term i) Most patients aren't truly comatose (but they are generally delirious) ii) Most patients don't have myxedema The construct of "myxedema coma" sets clinicians up for diagnostic failure Decompensated hypothyroidism may be conceptualized as hypothyroidism causing organ failure The first organ to fail is generally the Untreated or unrecognized hypothyroidism may progress to severe decompensated hypothyroidism or myxedema coma Relatively few cases are reported in the literature since the first case was apparently reported from the St Thomas Hospital in London in 1879 The paucity of cases may be due to either underreporting or improvement in the diagnosis and treatment of
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De très nombreux exemples de phrases traduites contenant "myxedema coma" – Dictionnaire françaisanglais et moteur de recherche de traductions françaises Cases of myxedema coma usually occur in women with a significant mortality rate (2560%) even when they are under proper treatment 2,3 Myxedematous coma is a syndrome that results from the intense reduction of the thyroid hormone synthesis There are some triggering factors like exposition to low temperatures, infections, irregularMyxedema crisis can cause death often due to complications from infection, bleeding, or respiratory failure It's more common in women and people over the age of 60 It can occur
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Other causes include severe uncontrolled diabetes mellitus , liver disease, kidney disease, and neurologic conditions Evaluation of a patient in a coma is comprehensive Canine myxedema coma is a rare, lifethreatening complication of hypothyroidism 17 In human beings the name myxedema coma is considered a misnomer, because human patients with this condition are rarely comatose and do not usually have myxedema 8,9 Diagnosis of myxedema coma is difficult because it is rare, and therefore little is known of the condition 1
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